My experience as the persuasion guy on health and safety projects quickly taught me to understand as well as I could the basic science behind any intervention I served. Part of that drive to knowledge was due to my unfortunate temperament that compels a ceaseless need to think about everything. The bigger part, however, came from getting burned by zealots parading as scientists who fooled me into thinking they had a Big TACT when all they had was either a Big Heart or a Big Ego. When you work in health and safety, you need to know the difference because you can waste limited resources feeding a fool rather than Changing the World. Consider this great example of plain old science.
A team of researchers took a sample of 99 zebra finches born from randomly paired adult birds in a captive population at a research facility. These 99 birds were then tracked from hatchlings to the natural end of their lives. Along the way this team studied the impact of diet and reproduction in one experiment, then kept the birds in safe cages until all naturally died. They waited 9 years. Throughout the study period, the researchers regularly took blood samples from each bird and measured the length of telomeres. I suspect you know as much about telomeres as I do, so you’ll appreciate an expert quotation rather than Sayings from Chairman Steve.
Telomeres are highly conserved, noncoding, repetitive sequences of DNA that, together with a number of shelterin proteins, form caps at the ends of eukaryotic chromosomes, enabling chromosome ends to be distinguished from double-stranded breaks (3). In the absence of restoration, telomeres shorten during each round of normal somatic cell division because RNA polymerase cannot completely replicate the lagging strand (3, 4). The loss of DNA from the telomeric cap protects the coding sequences from attrition and also limits cell replicative potential; once telomeres reach a critically shortened length, cells stop dividing and enter a state of replicative senescence (3, 5).
Telomeres are DNA contents that play a role in aging. As cells replicate normally across the lifespan, telomeres get shorter until they lose their protective function and the cells stop working. That’s basically why after a certain age you can’t touch your toes, eat or drink like you did, or remember where you put your keys. The telomeres run out which starts a cascade of change leading to cell death. The interesting question here is just how important telomeres are to the lifespan. The zebra finch study provides insight.
There was a highly significant relationship between early life telomere length and longevity: individuals that had longer telomeres at 25 d had a significantly longer lifespan (F1, 86.11 = 16.75, P < 0.001, Fig. 3).
You can translate the F = 16.75 into an effect size and you get a Large Windowpane of nearly 20/80. Birds born with longer telomere sequences through 25 days lived a lot longer than birds with shorter sequences. It’s also interesting to note that the length difference in telomeres exists at very young ages and does not carry over across the adult life span.
Telomere length declined with age (F [5, 158.92] = 20.92, P < 0.001), with loss being most marked during the first year (Fig. 1).
I cannot compute an effect size from this test, but the magnitude is not Small. Here’s a graph to illustrate it.

This suggests that if we can do anything to affect telomere size or depletion, we better do it young. If ever there was an interesting and potentially useful area for More Research, this must be it.
Let’s consider now longer life. Assuming that our cells are like zebra finch cells and that a telomere is a telomere is a telomere, it’s apparent that the cards you are dealt determines the hand you can play at a Large Windowpane. Now, contrast that against all the various Fairy Tale effects from the Lifestyle Drum and Bugle Corps. As I’ve frequently noted in the Persuasion Blog, people will cry out for a Change that isn’t even Small, yet something that requires Congressional action. Call this the Mallomar Redemption. Make laws about diet to Save the World.
Now, contrast the Mallomar Redemption with the Telomere Limit. A variety of well done lab studies creates a growing research literature that documents the Very Large impact of the factor. For now, the operation of telomeres is not widely understood and we certainly are forever and a day away from the pill. But, for now we can usefully quote Shakespeare, ” . . . the fault, dear Brutus, is not in our stars, but in ourselves . . . ”
See the feeble and foolish attempt to change telomeres with mallomars, as if we can affect this DNA function with broccoli and bean sprouts.
You Cannot Persuade a Falling Apple.
